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Moderate physical activity in relation to mammographic patterns.

I T Gram1, E Funkhouser, L Tabar

  • 1Institute of Community Medicine, University of Tromsø, Norway. inger.torhild.gram@ism.uit.no

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|March 6, 1999
PubMed
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Regular physical activity may reduce the likelihood of high-risk mammographic patterns, a potential indicator for breast cancer. Further research is needed to confirm this association and explore underlying biological mechanisms.

Area of Science:

  • Epidemiology
  • Public Health
  • Oncology

Background:

  • High-risk mammographic patterns serve as a surrogate endpoint in breast cancer research.
  • Physical activity is a potentially modifiable risk factor for breast cancer.

Purpose of the Study:

  • To investigate the association between physical activity levels and mammographic patterns in Norwegian women.
  • To determine if physical activity influences the likelihood of having high-risk mammographic patterns.

Main Methods:

  • A cohort of 2720 Norwegian women (ages 40-56) from the Tromsø studies provided questionnaire data on physical activity.
  • Mammograms were categorized into five patterns; patterns IV and V were defined as high-risk.
  • Logistic regression analysis, adjusted for multiple covariates, was used to estimate odds ratios and 95% confidence intervals.

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Main Results:

  • Women engaging in moderate physical activity (over 2 hours/week) showed a trend towards a 20% reduced likelihood of high-risk mammographic patterns (OR, 0.8; 95% CI, 0.6-1.1).
  • This trend was observed consistently across different menopausal statuses, parity, and body mass index categories.
  • However, all observed associations were weak, with confidence intervals including 1.0, suggesting chance as a plausible explanation.

Conclusions:

  • The study found a weak, non-statistically significant association between moderate physical activity and lower odds of high-risk mammographic patterns.
  • Further investigation is warranted to explore potential biological mechanisms linking physical activity to breast cancer risk.
  • While physical activity is a modifiable factor, its direct impact on mammographic patterns requires more robust evidence.