Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intermediate filament proteins in developing human arteries.

B Johansson1, A Eriksson, L E Thornell

  • 1Department of Anatomy, Umeå University, Sweden. bengt.johansson@anatomy.umu.se

Anatomy and Embryology
|March 6, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Spread of "triad diagnostics" in suspected Shaken Baby Syndrome" [Forensic Sci. Int. Synerg. (2026) 2 100660].

Forensic science international. Synergy·2026
Same author

Mortality and complications after percutaneous endoscopic gastrostomy: a retrospective multicentre study.

BMC gastroenterology·2022
Same author

The PERFORM-P (Principles of Evidence-based Reporting in FORensic Medicine-Pathology version).

Forensic science international·2021
Same author

Influence of collisions on ion dynamics in the inner comae of four comets.

Astronomy and astrophysics·2019
Same author

Is Delayed Speech Development a Long-Term Sequela of Birth-Related Subdural Hematoma?

AJNR. American journal of neuroradiology·2019
Same author

Firearm deaths in Sweden.

European journal of public health·2018
Same journal

Online First publication.

Anatomy and embryology·2014
Same journal

The postnatal development of the optic nerve of a reptile (Vipera aspis): A quantitative ultrastructural study.

Anatomy and embryology·2006
Same journal

Immunophenotyping and spatio-temporal distribution of aortic cell clusters in the bovine embryo.

Anatomy and embryology·2006
Same journal

Nitric oxide synthase-containing neurons in the amygdaloid nuclear complex of the rat.

Anatomy and embryology·2006
Same journal

Development of cerebral sulci and gyri in fetuses of cynomolgus monkeys (Macaca fascicularis).

Anatomy and embryology·2006
Same journal

Two endothelial cell lines derived from the somite.

Anatomy and embryology·2006
See all related articles

Intermediate filament protein distribution in human arteries changes significantly from neonate to adult. These postnatal changes in desmin and cytokeratins vary between elastic and muscular arteries.

Area of Science:

  • Vascular Biology
  • Cell Biology
  • Developmental Biology

Background:

  • The distribution of intermediate filament proteins in adult human blood vessels and fetal elastic arteries is known.
  • However, the developmental changes in these proteins from neonate to adult human arteries remain uncharacterized.

Purpose of the Study:

  • To investigate the postnatal distribution of intermediate filament proteins (desmin, vimentin, cytokeratins 8, 18, and 19) in human arteries.
  • To identify age-dependent and vessel-specific changes in intermediate filament protein expression.

Main Methods:

  • Human postnatal arteries were analyzed using immunohistochemistry.
  • Antibodies targeting desmin, vimentin, and cytokeratins 8, 18, and 19 were employed.

Main Results:

Related Experiment Videos

  • Vimentin was consistently present in smooth muscle cells across all ages and vessels.
  • Desmin expression increased in elastic arteries within the first year of life, with higher levels in the pulmonary trunk than the aorta.
  • Cytokeratin expression was observed earlier in the pulmonary trunk than the aorta, and throughout the ductus arteriosus wall, contrasting with localized desmin presence.

Conclusions:

  • Significant postnatal developmental changes occur in the distribution of intermediate filament proteins in human elastic and some muscular arteries.
  • The intermediate filament protein pattern remains stable in certain muscular arteries throughout postnatal development.