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Cellular proliferation in pilocytic and diffuse astrocytomas.

C Giannini1, B W Scheithauer, P C Burger

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.

Journal of Neuropathology and Experimental Neurology
|February 12, 1999
PubMed
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The MIB-1 labeling index (LI) is a significant predictor of survival in diffuse astrocytomas, outperforming other histologic factors in grades 2 and 3. This study suggests the St. Anne-Mayo grading scheme

Area of Science:

  • Neuro-oncology
  • Pathology
  • Cancer Biomarkers

Background:

  • Astrocytomas are primary brain tumors with varying prognoses.
  • Accurate prognostic markers are crucial for guiding treatment and predicting patient outcomes.
  • The MIB-1 labeling index (LI), a measure of cell proliferation, is increasingly used in tumor assessment.

Purpose of the Study:

  • To evaluate the MIB-1 labeling index (LI) in pilocytic and diffuse astrocytomas.
  • To determine the prognostic significance of MIB-1 LI for survival in astrocytoma patients.
  • To compare MIB-1 LI with established prognostic factors like tumor grade and histologic features.

Main Methods:

  • Quantitative image analysis was used to assess MIB-1 LI in 131 pilocytic and 140 diffuse astrocytomas.

Related Experiment Videos

  • Diffuse astrocytomas were classified into grades 2, 3, and 4 using the St. Anne-Mayo scheme.
  • MIB-1 LI was correlated with survival and other histologic parameters (atypia, mitoses, endothelial proliferation, necrosis).

    • Main Results:

    • MIB-1 LI was significantly higher in diffuse astrocytomas compared to pilocytic astrocytomas and increased with higher grades.
    • In diffuse astrocytomas, MIB-1 LI strongly correlated with tumor grade, mitotic activity, and patient survival.
    • Necrosis was the strongest predictor of survival in all diffuse astrocytoma grades; however, MIB-1 LI was the sole independent predictor in grades 2 and 3 on multivariate analysis.

    Conclusions:

    • MIB-1 LI is a valuable prognostic marker for diffuse astrocytomas, particularly in grades 2 and 3.
    • The findings suggest that the current cutoff points in the St. Anne-Mayo grading scheme for diffuse astrocytomas may require revision.
    • Further investigation into the optimal grading of diffuse astrocytomas based on proliferation markers like MIB-1 LI is warranted.