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Related Experiment Videos

[Doxycycline-induced esophageal ulcers].

J F Huizar1, I Podolsky, J Goldberg

  • 1Hospital ABC, México D.F.

Revista De Gastroenterologia De Mexico
|March 9, 1999
PubMed
Summary

Doxycycline can cause esophageal ulcers, with symptoms resolving within days of stopping the antibiotic. Sucralfate may coat ulcers but does not shorten symptom duration for these drug-induced esophageal injuries.

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Tetracycline antibiotics, including doxycycline, are known to cause esophageal ulcers.
  • Esophageal ulcers present with symptoms like dysphagia and odinophagia.

Purpose of the Study:

  • To investigate the behavior and treatment response of doxycycline-induced esophageal ulcers.
  • To evaluate the efficacy of sucralfate in managing these ulcers.

Main Methods:

  • Retrospective study of patients presenting with dysphagia and odinophagia after recent doxycycline use.
  • Upper GI endoscopy for diagnosis.
  • Discontinuation of doxycycline and treatment with sucralfate in some patients.

Main Results:

  • Eleven patients developed esophageal ulcers linked to doxycycline use for various infections and conditions.
  • Odinophagia was a common symptom, exacerbated by taking pills before bed with minimal water.
  • Ulcers were primarily located in the mid-esophagus.
  • Symptoms resolved in an average of 3.7 days after discontinuing doxycycline.
  • Sucralfate treatment did not alter the symptom resolution period.

Conclusions:

  • Doxycycline-induced esophageal ulcers require physician awareness.
  • Antibiotic discontinuation is the primary treatment; sucralfate does not improve outcomes.
  • Patient education on proper medication intake (sufficient fluids, upright position) is crucial.
  • Special attention should be given to elderly patients and those with pre-existing esophageal conditions.

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