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[Ceftriaxone-induced cholelithiasis].

M Maccherini1, G Borlini, M Branchi

  • 1Divisione di Pediatria, Ospedale Civile di Sondrio, Italia.

La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
|March 9, 1999
PubMed
Summary
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Ceftriaxone can cause biliary sludge and gallstones, especially in children. Stopping the antibiotic often resolves the issue, suggesting cautious use is warranted.

Area of Science:

  • Pediatric Gastroenterology
  • Pharmacology
  • Hepatobiliary Medicine

Background:

  • Ceftriaxone is a widely used antibiotic in pediatric care.
  • Biliary sludge and cholelithiasis are known potential side effects of ceftriaxone.
  • This adverse effect is underrecognized in gastroenterology and surgical literature.

Observation:

  • Two pediatric cases of ceftriaxone-induced cholelithiasis are presented.
  • Biliary sludge formation occurred following ceftriaxone administration.
  • Symptoms in affected patients necessitated intervention.

Findings:

  • Discontinuation of ceftriaxone led to prompt resolution of biliary sludge in reported cases.
  • Cholecystectomy was performed in symptomatic patients, despite potential for drug cessation to resolve the condition.

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  • The incidence and clinical significance of ceftriaxone-induced gallstones in children may be underestimated.

    • Implications:

    • Ceftriaxone should be prescribed with greater caution in pediatric populations due to the risk of cholelithiasis.
    • Increased awareness among clinicians is needed to recognize and manage this adverse drug effect.
    • Further research into the mechanisms and prevalence of ceftriaxone-induced gallstones is recommended.