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Updated: Aug 11, 2026

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
Published on: May 2, 2018
Type I beta-lactamases of Enterobacter cloacae and resistance to beta-lactam antibiotics
M T Tejedor-Junco1, M González-Martín, P Lupiola
1Departamento de Ciencias Clínicas, Microbiología, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain.
Abstract:
The interaction of type-I beta-lactamases from Enterobacter cloacae with diverse beta-lactam compounds was examined. The ability of penicillin and cefoxitin to induce beta-lactamase production in this strain was assessed. The effect of beta-lactamase inhibitors was measured on beta-lactamase extracts and on intact cells. E. cloacae 78 strain is a stably derepressed mutant showing limited susceptibility to a number of antibiotics except imipenem. Imipenem would therefore be the appropriate choice for therapy of infections caused by stably derepressed mutants of Enterobacter sp. producing type-I beta-lactamases.
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