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Non-coding plasmid DNA induces IFN-gamma in vivo and suppresses autoimmune encephalomyelitis
G L Boccaccio1, F Mor, L Steinman
1The Weizmann Institute of Science, Department of Immunology, Rehovot, Israel.
International Immunology
|March 9, 1999
Abstract:
Regulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine production in vivo. We demonstrate here that injection of plasmid DNA can suppress the prototypic T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis, by inducing IFN-gamma.