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Published on: August 31, 2010
Effect of a short-term dietary creatine supplementation on high-energy phosphates in the rat myocardium
Z Brzezińska1, K Nazar, H Kaciuba-Uściłko
1Department of Applied Physiology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
Abstract:
The aim of this study was to find out whether creatine (Cr) feeding affects total creatine (TCr), phosphocreatine (PCr), adenine nucleotide contents and beta-hydroxy-acyl-CoA-dehydrogenase (HAD) activity in myocardium as compared to red skeletal muscle. Ten adult Wistar rats received Cr (2.5% of diet weight) for 7 days. In Cr fed rats, PCr was increased (by approx. 20%) in cardiac and in soleus muscles with ATP elevated in myocardium and TCr and free Cr in soleus. In both muscles, Cr feeding enhanced HAD activity. It is concluded, that dietary Cr does increase cardiac muscle high energy phosphate reserves and its oxidative potential.
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