Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Consanguinity and recurrence risk of birth defects: a population-based study.

C Stoltenberg1, P Magnus, A Skrondal

  • 1Department of Population Health Sciences, National Institute of Public Health, Oslo, Norway.

American Journal of Medical Genetics
|March 9, 1999
PubMed
Summary

The recurrence risk for birth defects is higher in children of first-cousin parents compared to unrelated parents. This highlights the impact of increased homozygosity on birth defect recurrence risks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology.

medRxiv : the preprint server for health sciences·2025
Same author

The Association Between Tobacco Use and Risk of COVID-19 Infection and Clinical Outcomes in Sweden: A Population-Based Study.

International journal of public health·2023
Same author

The influence of immigrant background and parental education on overweight and obesity in 8-year-old children in Norway.

BMC public health·2023
Same author

Current tobacco use and COVID-19 diagnoses in a cohort of adult clients of public dental clinics in Sweden.

Scientific reports·2023
Same author

Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts.

BJOG : an international journal of obstetrics and gynaecology·2019
Same author

The interplay between cognitive ability, alcohol consumption, and health characteristics.

Psychological medicine·2017

Area of Science:

  • Medical Genetics
  • Reproductive Health
  • Population Health

Background:

  • Recurrence risks for birth defects are crucial for understanding causes and for genetic counseling.
  • Limited population-based data exists on birth defect recurrence in offspring of consanguineous parents.

Purpose of the Study:

  • To estimate and compare the recurrence risk of birth defects in subsequent siblings of first-cousin parents versus nonconsanguineous parents.

Main Methods:

  • Population-based study in Norway (1967-1995) including 660,398 children of nonconsanguineous parents and 3,583 children of first-cousin parents.
  • Analysis of birth defect recurrence in subsequent siblings based on parental consanguinity and previous sibling's birth defect status.

Main Results:

Related Experiment Videos

  • For nonconsanguineous parents, recurrence risks were 15/1,000 (no previous defect) and 33/1,000 (previous defect).
  • For first-cousin parents, recurrence risks were 36/1,000 (no previous defect) and 68/1,000 (previous defect).
  • The risk of birth defect recurrence is significantly higher for siblings of first-cousin parents.

Conclusions:

  • Consanguinity, specifically between first cousins, increases the risk of birth defect recurrence in subsequent siblings.
  • Increased homozygosity in offspring of consanguineous parents contributes to the elevated recurrence risk of birth defects.