Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nicotine-modified postinfarction left ventricular remodeling.

F J Villarreal1, D Hong, J Omens

  • 1Department of Medicine, University of California, San Diego, California, 92103, USA.

The American Journal of Physiology
|March 10, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of preoperative stoma education on postoperative outcomes for patients with new stomas after colorectal surgery: a systematic review and meta-analysis.

Techniques in coloproctology·2025
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Association, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, Vancouver, BC, Sept. 17-21, 2013.

Canadian journal of surgery. Journal canadien de chirurgie·2025
Same author

Starting position during colonoscopy: a systematic review and meta-analysis of randomized controlled trials.

Techniques in coloproctology·2024
Same author

The modified frailty index predicts postoperative morbidity in elective hernia repair patients: analysis of the national inpatient sample 2015-2019.

Hernia : the journal of hernias and abdominal wall surgery·2024
Same author

Cutting seton for the treatment of cryptoglandular fistula-in-ano: a systematic review and meta-analysis.

Techniques in coloproctology·2023
Same author

Prognostic value of cardiac magnetic resonance imaging feature tracking technology in patients with light chain amyloidosis.

Clinical radiology·2023
Same journal

Blood coagulation in fish.

The American journal of physiology·2011
Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010
Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010
Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010
Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010
Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010
See all related articles

Nicotine impairs cardiac wound healing after heart attack. This leads to enlarged left ventricles and thinner walls, increasing heart failure risk.

Area of Science:

  • Cardiovascular Science
  • Regenerative Medicine
  • Toxicology

Background:

  • Cigarette smoking is known to impede wound healing in various tissues.
  • The specific impact of nicotine on cardiac healing post-myocardial infarction is not well understood.

Purpose of the Study:

  • To investigate the adverse effects of nicotine on post-infarction cardiac wound healing and remodeling.
  • To evaluate nicotine's influence on left ventricular structure and function after myocardial infarction.

Main Methods:

  • Rats were divided into control and nicotine-treated groups (1.75 mg/day nicotine patch).
  • Anterior wall myocardial infarction was induced after a 7-day treatment period.
  • Hearts were analyzed after a 7-day healing period using mechanical and pressure-strain tests.

Related Experiment Videos

Main Results:

  • Nicotine-treated rats exhibited significantly enlarged left ventricles with thinner infarcted walls.
  • A rightward shift in the passive pressure-volume relationship was observed in nicotine-treated rats.
  • Pressure-strain analysis suggested altered material properties of the cardiac wound in the presence of nicotine.

Conclusions:

  • Nicotine adversely affects post-myocardial infarction healing and left ventricular remodeling.
  • These findings highlight potential clinical implications regarding heart failure risk in individuals exposed to nicotine.