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Tetrahymena pyriformis: a tool for toxicological studies. A review
M P Sauvant1, D Pepin, E Piccinni
1UFR Pharmacie, Laboratoire Hydrologie, Environnement et Santé Publique, Clermont-Ferrand, France.
Abstract:
Among protozoa, Tetrahymena pyriformis is the most commonly ciliated model used for laboratory research. After a brief description of the morphology and biology of Tetrahymena pyriformis, this article focuses on the most important and recent investigations performed with this species in toxicology and ecotoxicology. The methodological features of its culture, and main tests, based on cell growth rate, biochemical markers, behavioral changes and motility, are discussed. Examples of xenobiotics (organic and inorganic substances, pharmaceutical drugs, water pollutants) tested with Tetrahymena pyriformis are also given.