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Related Experiment Video

Updated: Jun 26, 2026

Breathing-controlled Electrical Stimulation (BreEStim) for Management of Neuropathic Pain and Spasticity
11:34

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Published on: January 10, 2013

Percutaneous electrical nerve stimulation for low back pain: a randomized crossover study.

E A Ghoname1, W F Craig, P F White

  • 1Eugene McDermott Center for Pain Management, Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas 75235-9068, USA.

JAMA
|March 10, 1999
PubMed
Summary
This summary is machine-generated.

Percutaneous electrical nerve stimulation (PENS) offers superior short-term relief for chronic low back pain compared to TENS and exercise. PENS significantly reduced pain scores and analgesic use, improving physical function and sleep quality.

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Area of Science:

  • Pain Management
  • Neuromodulation
  • Physical Therapy

Background:

  • Low back pain (LBP) is a leading cause of disability and economic loss in the US.
  • Current pharmacological treatments for LBP have limited efficacy and significant side effects.

Purpose of the Study:

  • To evaluate the effectiveness of percutaneous electrical nerve stimulation (PENS) for long-term low back pain.
  • To compare PENS against transcutaneous electrical nerve stimulation (TENS) and exercise therapy.

Main Methods:

  • A randomized, single-blinded, sham-controlled, crossover study involving 60 patients with chronic LBP.
  • Four treatment modalities were administered: sham-PENS, PENS, TENS, and exercise.
  • Outcomes included visual analog scale (VAS) pain scores, analgesic use, physical activity, sleep quality, and SF-36 scores.

Main Results:

  • PENS significantly reduced VAS pain scores more than sham-PENS, TENS, and exercise.
  • PENS therapy decreased daily analgesic intake by 50% compared to baseline.
  • Patients reported PENS as the most effective modality for LBP relief, with significant improvements in physical activity, sleep, and well-being.

Conclusions:

  • Percutaneous electrical nerve stimulation (PENS) is an effective nonpharmacologic therapy for short-term management of chronic low back pain.
  • PENS demonstrated superior efficacy over TENS and exercise in improving pain, function, and quality of life.