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Soluble forms of CD95 and CD95 ligand after living related liver transplantation
K Seino1, N Kayagaki, N Yamaguchi
1Department of Surgery, University of Tsukuba School of Medicine, Ibaraki, Japan. mo97g074@md.tsukuba.ac.jp
Background:
Soluble forms of CD95 and CD95 ligand (sCD95 and sCD95L, respectively) can increase in the serum of patients with some inflammatory disease. In this study, we investigated the serum levels of sCD95 and sCD95L in liver transplantation recipients.
Methods:
Serum levels of sCD95 and sCD95L in living related liver transplant recipients were analyzed by ELISA and their relation to the clinical findings estimated.
Results:
Serum samples from the recipients did not show detectable levels of sCD95L but showed significantly increased levels of sCD95. The increase of sCD95 was positively associated with that of total-bilirubin and incidence of rejection, infection, and graft ischemia.
Conclusions:
The present results indicate an existence of sCD95 in the recipients of living related liver transplants. The increased serum levels of sCD95 may modify the immunological situation of the recipients after transplantation or represent the ongoing graft damage.