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Sezary cells with hairy projections.
Leukemia Research
|March 10, 1999
Summary
This report details a rare Sezary syndrome case. Sezary cells exhibited unique cytoplasmic hairy projections, aiding diagnosis in this T-cell lymphoma.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Sezary syndrome is a rare form of cutaneous T-cell lymphoma.
- It is characterized by exfoliative erythroderma, lymphadenopathy, and circulating atypical lymphocytes (mycosis fungoides).
Observation:
- A patient presented with classic exfoliative erythroderma and elevated white blood cell count.
- Peripheral blood analysis revealed atypical lymphocytes with characteristic folded nuclei.
Findings:
- The Sezary cells in this case displayed distinct cytoplasmic hairy projections.
- Ultrastructural examination confirmed cerebriform nuclei and these unique cytoplasmic projections.
Implications:
- These findings expand the understanding of Sezary cell morphology.
- Recognizing these cytoplasmic projections may aid in the diagnosis of challenging Sezary syndrome cases.
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