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Intramuscular mixed tumour with clonal chromosomal changes.

P Pauwels1, P Dal Cin, R Roumen

  • 1Stichting PAMM, Carharinaziekenhuis, Eindhoven, The Netherlands.

Virchows Archiv : an International Journal of Pathology
|March 10, 1999
PubMed
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This case study describes an intramuscular mixed tumor in an 82-year-old man. Cytogenetic analysis was crucial for differentiating it from extraskeletal myxoid chondrosarcoma (EMC).

Area of Science:

  • Oncology
  • Pathology
  • Cytogenetics

Background:

  • Intramuscular mixed tumors are rare neoplasms.
  • Accurate diagnosis is essential for appropriate patient management.

Observation:

  • An 82-year-old male presented with a large mass in his right triceps muscle.
  • Histopathology revealed a lobulated tumor with epithelioid cells in a chondromyxoid stroma.
  • Immunohistochemistry showed S100 protein and pancytokeratin positivity.

Findings:

  • Cytogenetic analysis identified complex clonal chromosomal abnormalities: 47, XY, +i(2) (q10), -15, der(17) t(15; 17) (q11; p12), +r.
  • Extraskeletal myxoid chondrosarcoma (EMC) typically exhibits a specific translocation t(9;22).

Implications:

Related Experiment Videos

  • Distinguishing intramuscular mixed tumors from EMC can be challenging, especially with incisional biopsies.
  • Cytogenetic analysis is a valuable tool for differential diagnosis, aiding in accurate classification and treatment planning.