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Responses of renal function to elevated intravesical pressure
N Dangas1, E Parashou, M Lymberi
1Department of Urology, Hippokration General Hospital, Athens, Greece.
British Journal of Urology
|November 1, 1993
Summary
Elevated bladder pressure significantly reduces kidney function, decreasing urine output and glomerular filtration rate (GFR). A vesicorenal reflex likely mediates these effects, highlighting the impact of bladder distension on renal health.
Area of Science:
- Nephrology
- Urology
- Physiology
Background:
- Elevated intravesical pressure can impact renal function.
- Understanding the mechanisms behind these changes is crucial for clinical management.
Purpose of the Study:
- To investigate the effects of increased intravesical pressure on renal function.
- To determine the role of a potential vesicorenal reflex.
Main Methods:
- Ten male New Zealand rabbits underwent ureterocutaneous urinary diversion.
- Renal function was assessed by measuring urine output and glomerular filtration rate (GFR) using 51Cr-EDTA clearance.
- Intravesical pressure was elevated to 60 cm H2O.
Main Results:
- A significant decrease in urine output was observed.
- Glomerular filtration rate (GFR) also significantly decreased.
- Renal function returned to baseline after pressure relief.
Conclusions:
- Elevated intravesical pressure adversely affects renal function.
- A vesicorenal reflex activated by bladder distension is likely responsible for these changes.