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Related Experiment Videos

Responses of renal function to elevated intravesical pressure.

N Dangas1, E Parashou, M Lymberi

  • 1Department of Urology, Hippokration General Hospital, Athens, Greece.

British Journal of Urology
|November 1, 1993
PubMed
Summary

Elevated bladder pressure significantly reduces kidney function, decreasing urine output and glomerular filtration rate (GFR). A vesicorenal reflex likely mediates these effects, highlighting the impact of bladder distension on renal health.

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Area of Science:

  • Nephrology
  • Urology
  • Physiology

Background:

  • Elevated intravesical pressure can impact renal function.
  • Understanding the mechanisms behind these changes is crucial for clinical management.

Purpose of the Study:

  • To investigate the effects of increased intravesical pressure on renal function.
  • To determine the role of a potential vesicorenal reflex.

Main Methods:

  • Ten male New Zealand rabbits underwent ureterocutaneous urinary diversion.
  • Renal function was assessed by measuring urine output and glomerular filtration rate (GFR) using 51Cr-EDTA clearance.
  • Intravesical pressure was elevated to 60 cm H2O.

Main Results:

  • A significant decrease in urine output was observed.

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  • Glomerular filtration rate (GFR) also significantly decreased.
  • Renal function returned to baseline after pressure relief.

    • Conclusions:

    • Elevated intravesical pressure adversely affects renal function.
    • A vesicorenal reflex activated by bladder distension is likely responsible for these changes.