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A study of motor dysfunction associated with schizophrenia based on analyses of movement-related cerebral potentials
F Kubota1, H Miyata, N Shibata
1Department of Neuropsychiatry, Gunma University School of Medicine, Japan.
Background:
Several reports have shown that schizophrenics have motor dysfunction. The aim of this study was to identify the site of the nerve damage responsible for the motor dysfunction in schizophrenics by measuring both movement-related cerebral potentials (MRCPs) and motor conduction times.
Methods:
The subjects were 27 patients and 31 controls. There was no significant difference in age, nor in the length of the subjects' arms between the two groups. MRCPs were recorded during voluntary self-paced index movements of the thumb. The motor nerve conduction time was determined by magnetically stimulating the motor cortex and the spinal root.
Results:
Six of 27 schizophrenics had normal MRCPs, but the remaining 21 showed abnormal MRCPs. Of the 31 controls, 27 were normal, whereas 4 showed abnormal MRCPs. The difference between the two groups was significant; however, no significant differences were found in the motor conduction times, the motor root conduction times, or the central motor conduction times between the two groups.
Conclusions:
Our results suggest that the responsible focus of motor nerve disorder in schizophrenia lies in the motor-integrating system in frontal lobe, and not in the nervous conduction system from the brain to the muscles.