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Apolipoprotein E-epsilon 4 frequency in affective disorder.

L V Kessing1, O S Jørgensen

  • 1Department of Psychiatry, University of Copenhagen, Rigshospitalet, Denmark.

Biological Psychiatry
|March 11, 1999
PubMed
Summary
This summary is machine-generated.

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The apolipoprotein E (APOE) epsilon 4 allele is not linked to cognitive impairment in affective disorders. Cognitive decline in these conditions likely stems from other biological factors, not APOE genotype.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • The apolipoprotein E (APOE) epsilon 4 allele is a known risk factor for Alzheimer's disease.
  • Affective disorders are also associated with Alzheimer's disease.
  • The role of APOE epsilon 4 in cognitive impairment within affective disorders remains unclear.

Purpose of the Study:

  • To investigate the association between the APOE epsilon 4 allele and cognitive function in patients with affective disorders.
  • To determine if APOE genotype influences cognitive impairment subtypes in unipolar and bipolar disorder.

Main Methods:

  • Genotyping for APOE was performed on 106 unipolar patients, 21 bipolar patients, and 46 controls.
  • Cognitive function was assessed using multiple standardized tests during the euthymic phase.

Related Experiment Videos

  • APOE genotype frequencies were compared between patient groups and controls and correlated with cognitive scores.

    • Main Results:

    • APOE epsilon 4 allele frequencies were similar among unipolar patients, bipolar patients, and controls.
    • No significant correlation was found between the APOE epsilon 4 allele and cognitive impairment.
    • Subgroup analyses did not reveal increased APOE epsilon 4 frequency associated with demographic or clinical factors.

    Conclusions:

    • Cognitive impairment in affective disorders appears to be mediated by mechanisms independent of the APOE genotype.
    • The APOE epsilon 4 allele does not seem to be a significant factor in the cognitive deficits observed in affective disorders.