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Related Experiment Videos

Fundoplication wrap disruption: an experimental study in rats.

J D Urschel1, N J Petrelli

  • 1Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY 14263-0001, USA.

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
|March 11, 1999
PubMed
Summary

Complete and partial fundoplication wraps showed similar resistance to disruption in a rat model. This suggests that wrap type may not significantly impact the mechanical strength of antireflux surgery, potentially influencing long-term outcomes.

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Area of Science:

  • Gastroenterology
  • Surgical Research
  • Biomechanical Engineering

Background:

  • Antireflux surgery offers long-term gastroesophageal reflux disease control.
  • Late surgical failures can result from fundoplication wrap disruption.
  • Disruption is hypothesized to occur due to mechanical stresses on sutures.

Purpose of the Study:

  • To compare the mechanical strength of complete versus partial fundoplication wraps.
  • To test the hypothesis that complete wraps better withstand disruptive forces.

Main Methods:

  • Forty-eight rats underwent either partial or complete fundoplication.
  • Fundoplication wraps were tested using a bursting pressure technique (stomach distension).
  • Wraps were also tested for breaking strength using a tensiometer.

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Main Results:

  • Bursting pressures were statistically similar between partial (103.7 mmHg) and complete (100.5 mmHg) wraps.
  • Breaking strengths were also equivalent, with partial wraps disrupting at 6.69 N and complete wraps at 6.52 N.
  • In both groups, disruptions primarily occurred via sutures tearing through the stomach wall.

Conclusions:

  • This rat study found no significant difference in the mechanical resistance of partial and complete fundoplication wraps.
  • Both wrap types demonstrated similar susceptibility to suture pull-out from the stomach wall.
  • Findings do not support the hypothesis that complete fundoplications offer superior mechanical durability.