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Related Experiment Videos

Thermal behavior and dissolution properties of naproxen from binary and ternary solid dispersions.

P Mura, M T Faucci, A Manderioli

    Drug Development and Industrial Pharmacy
    |March 11, 1999
    PubMed
    Summary

    Solid dispersions of naproxen (NAP) with polyethylene glycol (PEG) and surfactants improved drug dissolution. Ternary systems containing anionic surfactants showed the best performance and stability over 30 months.

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    Area of Science:

    • Pharmaceutical Sciences
    • Materials Science

    Background:

    • Solid dispersions are crucial for enhancing the solubility and bioavailability of poorly soluble drugs like naproxen (NAP).
    • Polyethylene glycol (PEG) and surfactants are commonly used excipients in solid dispersion formulations to improve drug release.

    Purpose of the Study:

    • To investigate the effect of different molecular weights of PEG and types of surfactants on the physicochemical properties and dissolution behavior of naproxen solid dispersions.
    • To evaluate the long-term stability of these solid dispersions.

    Main Methods:

    • Naproxen solid dispersions were prepared using the melting method with various PEG molecular weights (4000, 6000, 20,000) and surfactants (sodium dodecyl sulfate - SDS, Tween 80 - Tw80).
    • Physicochemical characterization involved differential scanning calorimetry (DSC) and X-ray diffraction (XRD).

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  • Dissolution studies were conducted to assess drug release profiles, and stability was evaluated after 30 months of storage.

    • Main Results:

    • Ternary systems (drug-PEG-surfactant) exhibited enhanced drug dissolution compared to binary systems (drug-PEG).
    • The molecular weight of PEG did not significantly influence drug dissolution.
    • Anionic surfactant (SDS) demonstrated superior performance, attributed to its hydrophilicity and solubilizing power.
    • Solid dispersions showed good stability over 30 months, with only a minor decrease in dissolution rate at high SDS concentrations.

    Conclusions:

    • Incorporation of surfactants, particularly anionic ones like SDS, significantly improves the dissolution properties of naproxen solid dispersions.
    • The prepared solid dispersions are stable over extended storage periods, maintaining their drug release characteristics.
    • These findings highlight the potential of surfactant-modified PEG-based solid dispersions for enhancing naproxen bioavailability.