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Ibuprofen agglomerates preparation by phase separation.

M Jbilou1, A Ettabia, A M Guyot-Hermann

  • 1Laboratoire de Pharmacie Galénique, Lille, France.

Drug Development and Industrial Pharmacy
|March 11, 1999
PubMed
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Researchers developed a simple crystallization method to create ibuprofen spherical agglomerates. These agglomerates exhibit improved compression and dissolution properties, offering a direct route to better drug formulations.

Area of Science:

  • Pharmaceutical Science
  • Materials Science

Background:

  • Poor compression and dissolution rates of ibuprofen limit its formulation efficacy.
  • Current optimization methods often involve complex formulation processes.

Purpose of the Study:

  • To develop a direct crystallization method for producing ibuprofen particles with enhanced compression and dissolution properties.
  • To create spherical ibuprofen agglomerates suitable for direct compression and rapid dissolution.

Main Methods:

  • Utilized a simple crystallization technique involving phase separation in an ethanol/water mixture.
  • Cooled an ibuprofen-saturated solution in a 50/50 ethanol/water mixture, inducing crystallization within separated water droplets.
  • Characterized the resulting spherical agglomerates using scanning electron microscopy and X-ray powder diffraction.

Related Experiment Videos

  • Assessed compression ability with an instrumented tablet machine and dissolution rate via continuous flow cells.

    • Main Results:

    • Successfully produced ibuprofen spherical agglomerates with improved physical properties.
    • Observed significant enhancements in both compression ability and dissolution rate of the produced agglomerates.
    • Demonstrated the feasibility of crystallization in a dispersed phase for optimizing drug properties.

    Conclusions:

    • The developed crystallization method effectively produces ibuprofen spherical agglomerates with superior compression and dissolution characteristics.
    • This approach offers a promising strategy for direct drug particle engineering, bypassing complex formulation steps.
    • The principle is applicable to other drugs with opposing solubilities in miscible solvents.