Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pediatric tetracycline-induced pseudotumor cerbri.

A G Quinn1, S B Singer, J R Buncic

  • 1Department of Ophthalmology, The Hospital For Sick Children, University of Toronto, Ontario, Canada.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
|March 11, 1999
PubMed
Summary

Tetracycline antibiotics can cause pseudotumor cerebri in children, a condition previously underreported in this age group. Prompt treatment is crucial for avoiding long-term complications in pediatric patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

De novo subacute cutaneous lupus erythematosus-like eruptions in the setting of programmed death-1 or programmed death ligand-1 inhibitor therapy: clinicopathological correlation.

Clinical and experimental dermatology·2020
Same author

Management of patients in a combined thyroid eye clinic in secondary care.

International ophthalmology·2013
Same author

Charged nanoparticle dynamics in water induced by scanning transmission electron microscopy.

Langmuir : the ACS journal of surfaces and colloids·2012
Same author

National survey of the use of intraoperative antibiotics for prophylaxis against postoperative endophthalmitis following cataract surgery in the UK.

The British journal of ophthalmology·2010
Same author

Probing Planck's law with incandescent light emission from a single carbon nanotube.

Physical review letters·2009
Same author

Ocular tilt reaction and internuclear ophthalmoplegia associated with venous sinus thrombosis: an unusual case.

The British journal of ophthalmology·2008

Area of Science:

  • Neurology
  • Pediatrics
  • Ophthalmology

Background:

  • Tetracyclines are known to cause pseudotumor cerebri in adults.
  • The occurrence of this condition in pediatric patients treated with tetracyclines is not well-characterized.
  • This study presents six pediatric cases to clarify the condition, patient profile, treatment response, and sequelae.

Purpose of the Study:

  • To investigate the occurrence and characteristics of pseudotumor cerebri in pediatric patients exposed to tetracyclines.
  • To delineate the patient profile, treatment response, and potential long-term effects.
  • To raise awareness among physicians treating children with tetracyclines about this potential complication.

Main Methods:

  • Retrospective analysis of patient records at the Hospital For Sick Children, Toronto.

Related Experiment Videos

  • Inclusion criteria: diagnosis of pseudotumor cerebri and documented tetracycline use prior to presentation.
  • Study period: January 1, 1986, to March 1, 1996.

    • Main Results:

    • Six pediatric patients (ages 12-17, 5 female) were identified, all treated for acne vulgaris.
    • Symptoms included headache, nausea, and diplopia; most patients were in the upper quartile for BMI.
    • All patients responded to treatment, with symptom resolution within 1 day to 4 weeks and no long-term visual sequelae.

    Conclusions:

    • Pseudotumor cerebri associated with tetracycline-class drugs can occur in the pediatric population.
    • Prompt medical intervention can almost always prevent long-term sequelae.
    • Physicians must be aware of this potential adverse effect in children prescribed tetracyclines.