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Serum macrophage colony-stimulating factor (M-CSF) level is elevated in patients with old cerebral infarction related
A Suehiro1, H Tsujioka, H Yoshimoto
1Second Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan. suehiro@hyo-med.ac.jp
Insights
Elevated macrophage colony-stimulating factor (M-CSF) levels are linked to vascular damage and thrombosis in patients with old cerebral infarction. This finding suggests M-CSF may serve as a biomarker for post-stroke vascular health.
Area of Science:
- Biochemistry
- Vascular Biology
- Neurology
Background:
- Cerebral infarction, or stroke, can lead to long-term vascular complications.
- Assessing markers of vascular damage and thrombotic states is crucial for managing patients post-stroke.
Purpose of the Study:
- To investigate the association between serum macrophage colony-stimulating factor (M-CSF) levels and markers of vascular damage and thrombosis in patients with old cerebral infarction.
- To determine if M-CSF levels correlate with established indicators of endothelial dysfunction and coagulation activation.
Main Methods:
- Serum M-CSF levels were measured in 37 patients with old cerebral infarction and 41 healthy controls.
- Plasma levels of von Willebrand factor antigen (vWF), thrombomodulin (TM), thrombin-antithrombin III (TAT) complex, prothrombin fragment 1+2 (F1+2), D-dimer, and plasmin-antiplasmin (PAP) complex were quantified.
- Statistical analyses were performed to compare levels between groups and assess correlations.
Main Results:
- Patients with old cerebral infarction exhibited significantly higher serum M-CSF levels compared to healthy controls (1320.4 ± 410.6 vs. 853.9 ± 180.3 unit/ml, P < 0.01).
- Elevated plasma levels of vWF, TM, TAT, F1+2, D-dimer, and PAP complex were observed in patients versus controls (P < 0.05 for all).
- Significant positive correlations were found between M-CSF levels and all measured markers of vascular damage and thrombosis (P < 0.01).
Conclusions:
- Increased serum M-CSF levels are associated with vascular damage and a pro-thrombotic state in patients with established cerebral infarction.
- M-CSF may serve as a valuable biomarker for identifying ongoing vascular pathology and thrombotic risk in the chronic phase of stroke.
Abstract:
We measured the serum levels of macrophage colony-stimulating factor (M-CSF) in 37 patients with an old cerebral infarction who had been surmised to have a damaged vessel wall and who had been in a stable condition for over three months after stroke onset, and those of 41 healthy control subjects. The M-CSF levels in the patients were significantly higher (P < 0.01) than those of the controls at 1320.4 +/- 410.6 unit/ml and 853.9 +/- 180.3 unit/ml, respectively. The plasma levels of von Willebrand factor (vWF) antigen (P < 0.01) and thrombomodulin (TM) (P < 0.05), as well as those of thrombin-antithrombin III (TAT) complex (P < 0.05), prothrombin fragment 1+2 (F1+2) (P < 0.02), D-dimer products of crosslinked fibrin degradation products (D-dimer) (P < 0.01), and plasmin-antiplasmin (PAP) complex (P < 0.05) in the patients were also significantly higher than those in the controls. Significant positive correlations (P < 0.01) were found between these parameters and the M-CSF level, but there was no significant correlation between the M-CSF level and the white blood cell count, serum lipids, or blood pressure. Based on these results, we suggest that an increased M-CSF level indicates vascular damage or a thrombotic state in patients with an old cerebral infarction.