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Protection from digoxin-induced coronary vasoconstriction in patients with coronary artery disease by calcium
The American Journal of Cardiology
|March 11, 1999
Insights
Intravenous digoxin narrows coronary arteries, potentially causing ischemia in heart disease patients. Pretreatment with oral nisoldipine and intracoronary nitroglycerin effectively prevents this adverse effect.
Area of Science:
- Cardiology
- Pharmacology
- Clinical Medicine
Background:
- Intravenous digoxin can cause coronary artery constriction.
- This effect poses a risk of ischemic complications in patients with coronary artery disease.
Purpose of the Study:
- To investigate the effect of intravenous digoxin on coronary arteries.
- To determine if pretreatment with nisoldipine and nitroglycerin can prevent digoxin-induced coronary constriction.
Main Methods:
- Study involved patients with coronary artery disease.
- Assessed coronary artery response to intravenous digoxin.
- Evaluated the impact of pretreatment with oral nisoldipine and intracoronary nitroglycerin.
Main Results:
- Intravenous digoxin induced constriction in both normal and stenotic coronary arteries.
- Pretreatment with oral nisoldipine and intracoronary nitroglycerin successfully neutralized the digoxin-induced vasoconstriction.
Conclusions:
- Digoxin administration can lead to potentially harmful coronary artery constriction.
- Nisoldipine and nitroglycerin offer a protective strategy against digoxin-induced coronary vasoconstriction in patients with coronary artery disease.
Abstract:
Intravenous digoxin induces constriction of normal and stenotic coronary arteries in patients with coronary artery disease, which may lead to ischemic complications. We found that pretreatment with oral nisoldipine and intracoronary nitroglycerin neutralizes this digoxin-induced effect.