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Ras caught in another affair: the exchange factors for Ral
1Laboratory for Physiological Chemistry, Center for Biomedical Genetics,Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Current Opinion in Genetics & Development
|March 11, 1999
Abstract:
The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of transcription.