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Updated: Aug 12, 2026

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement
Published on: January 19, 2017
The regulation of replication origin activation
1CRC Chromosome Replication Group, Wellcome Trust Building, University of Dundee, Dundee DD1 5EH, UK. adonaldson@bad.dundee.ac.uk
Abstract:
At the start of the cell-division programme, proteins must be assembled onto replication origins to establish competence for initiation of DNA synthesis. At the correct moment, other effectors must then coordinate appropriate firing of the various origins to control entry into and progress through S phase. These processes are key targets of cell-cycle control, and understanding their regulation will provide a deeper knowledge of the mechanisms controlling cell proliferation.
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