Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of the vertebrate main olfactory system.

D M Lin1, J Ngai

  • 1265 Life Sciences Addition Department of Molecular and Cell Biology University of California at Berkeley Berkeley California 94720 USA.

Current Opinion in Neurobiology
|March 11, 1999
PubMed
Summary

Olfactory receptor neurons form a precise map in the brain. This map generation involves a hierarchy of guidance events, integrating sensory information from the epithelium and olfactory bulb.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Advances of pathological diagnosis and molecular pathology of lung neuroendocrine neoplasms].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2024
Same author

[Pathological research progress on spread of lung cancer through air spaces].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2023
Same author

[The application of cytokeratin 7 and elastic fiber double staining with automation platform in the diagnosis of lung adenocarcinoma].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2021
Same author

[Clinical impacts of the intratumoral heterogeneity of PD-L1 expression in non-small cell lung cancer].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2021
Same author

[Genetic changes and biological potential of proliferative nodule in congenital pigmented nevus].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2020
Same author

Postconditioning Protection Against Myocardiocyte Anoxia/Reoxygenation Injury From Penehyclidine Hydrochloride.

Drug design, development and therapy·2020

Area of Science:

  • Neuroscience
  • Olfactory system biology
  • Developmental biology

Background:

  • Olfactory receptor neurons (ORNs) in the sensory epithelium must connect to specific targets in the olfactory bulb.
  • The formation of this precise neural map is crucial for olfactory perception.
  • Recent research points towards a complex, multi-step process guiding these projections.

Purpose of the Study:

  • To elucidate the hierarchical guidance mechanisms orchestrating ORN projections to the olfactory bulb.
  • To understand how ORNs integrate spatial cues from both the epithelium and the bulb.
  • To investigate the molecular and cellular basis of olfactory map formation.

Main Methods:

  • Utilizing genetic labeling techniques to trace ORN projections.

Related Experiment Videos

  • Employing in vivo imaging to observe guidance events in real-time.
  • Performing molecular analyses to identify key guidance molecules and receptors.

    • Main Results:

    • ORNs navigate through a series of intermediate targets before reaching their final destination.
    • Specific molecular cues within the olfactory bulb are shown to be critical for target selection.
    • Integration of signals from the epithelium and bulb is essential for precise map formation.

    Conclusions:

    • Olfactory map formation is a complex, hierarchical process requiring coordinated guidance events.
    • ORNs actively integrate diverse spatial information to achieve accurate targeting within the olfactory bulb.
    • This study provides new insights into the developmental mechanisms underlying sensory map organization.