Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Eph receptors and ephrins in neural development.

D D O'Leary1, D G Wilkinson

  • 1Molecular Neurobiology Laboratory The Salk Institute 10010 North Torrey Pines Road La Jolla California 92037 USA. dennis_oleary@qm.salk.edu

Current Opinion in Neurobiology
|March 11, 1999
PubMed
Summary

Ephrins, ligands for Eph receptor tyrosine kinases, guide nervous system development by repelling axons and restricting cell movement. Emerging research reveals their broader functions in various tissues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Galantamine: a new treatment for Alzheimer's disease.

Expert review of neurotherapeutics·2009
Same author

Altered hormonal regulation and blood flow distribution with cardiovascular deconditioning after short-duration head down bed rest.

Journal of applied physiology (Bethesda, Md. : 1985)·2007
Same author

Heterogeneity of responses to orthostatic stress in homozygous twins.

Journal of applied physiology (Bethesda, Md. : 1985)·2006
Same author

Splanchnic and peripheral vascular resistance during lower body negative pressure (LBNP) and tilt.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2005
Same author

Test-retest repeatability of muscle sympathetic nerve activity: influence of data analysis and head-up tilt.

Autonomic neuroscience : basic & clinical·2004
Same author

Did knowledge, opinions, background, and health authority advice influence early prescribing of the novel Alzheimer's disease drug donepezil in general practice?--national postal survey.

Pharmacoepidemiology and drug safety·2004

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Signaling

Background:

  • Ephrins are ligands that bind to Eph receptor tyrosine kinases.
  • They play crucial roles in the development of the central and peripheral nervous systems.

Purpose of the Study:

  • To characterize the function and signaling of ephrins.
  • To explore the roles of ephrins in various tissues.

Main Methods:

  • The study reviews recent findings on ephrin function and signaling.
  • It synthesizes information on their roles in nervous system development and other tissues.

Main Results:

  • Ephrins typically act as repellents during development.
  • They influence axon pathfinding, topographic mapping, and cell migration.

Related Experiment Videos

  • Ephrins have significant roles beyond the nervous system.

    • Conclusions:

    • Ephrins are essential regulators of developmental processes.
    • Further research is characterizing their signaling mechanisms and broader tissue functions.