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Related Experiment Videos

Urolithiasis and the protease inhibitor indinavir.

J Hermieu1, M Prévot, V Ravery

  • 1Department of Urology, Bichat Hospital, Paris, France.

European Urology
|March 11, 1999
PubMed
Summary

Indinavir treatment in HIV patients can cause urolithiasis (kidney stones) in 9% of cases. Hydration and urine acidification are key to managing and preventing these stones.

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Area of Science:

  • Nephrology
  • Urology
  • Infectious Diseases

Background:

  • Protease inhibitors like indinavir are crucial in managing HIV.
  • Urological complications associated with indinavir therapy require careful evaluation.

Purpose of the Study:

  • To assess the incidence and characteristics of urological abnormalities in patients receiving indinavir.
  • To identify risk factors and management strategies for indinavir-induced urolithiasis.

Main Methods:

  • A cohort of 155 HIV-positive patients treated with indinavir was monitored.
  • Patients experiencing flank pain underwent clinical, laboratory, and imaging examinations.

Main Results:

  • Nine percent (14/155) of patients developed severe flank pain, indicative of urolithiasis.

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  • Diagnostic imaging revealed upper-tract dilatation and obstruction; indinavir crystals were identified in stones.
  • Renal insufficiency occurred in some patients, with ureteral stenting required in 4 cases.

    • Conclusions:

    • Indinavir therapy is associated with a 9% risk of urolithiasis.
    • Effective management involves hydration, analgesia, and urine acidification.
    • Prophylactic measures, including hydration and urine acidification, are vital for preventing complications.