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Reference typing report for complement components C6, C7 and C9 including mutations leading to deficiencies

R Würzner1, K Witzel-Schlömp, K Tokunaga

  • 1Institute of Hygiene, Leopold Franzens University, Innsbruck, Austria. reinhard.wuerzner@uibk.ac.at

Experimental and Clinical Immunogenetics
|March 11, 1999
PubMed

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Complementation Tests00:49

Complementation Tests

A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...