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[Changes of plasma endothelium-derived relaxing factor and endothelin-1 in patients with chronic cor pulmonale at
Abstract
Objective:
The authers investigated the levels of plasma EDRF-nitric oxide (NO) and ET-1 in 10 cases of cor pulmonale at exercise.
Methods:
Using the technologies of cardiac catheter, radioimmunization and biochemical analysis.
Results:
The level of plasma NO was lower in group A (mean pulmonary artery pressure (mPAP) < 2.67 kPa) than in group B (mPAP > or = 2.67 kPa) at rest; the content of plasma NO increased more markedly in group A than in group B during exercise; there was no change in the content of ET-1 in both groups; mPAP strongly correlated with plasma NO or ET-1 in both groups.
Conclusions:
The patients with cor pulmonale at early stage may be in a state of compensated release of NO, but its release reserve has been reduced.