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[Expression of FGF-b and C-myc in rats lung tissue affected by hypoxia]
Objective:
To study FGF's roles in the reconstruction of vascular walls owing to chronic hypoxia.
Method:
40 SD rats [corrected] were divided into different hypoxia groups and proceeded with various hypoxic intervals. Expression of FGF-b and transcription of c-myc mRNA of the rats [corrected] lung tissues were detected by immunohistochemical method and in situ hybridization.
Results:
FGF-b increased obviously in the smooth muscle and advential tissue of pulmonary arteries after 14 days of hypoxia, whereas C-myc mRNA showed overexpression in rats [corrected] lung tissue from 7th to 21st day of hypoxia.
Conclusion:
(1) Hypoxia may lead to activation of C-myc oncogene and increase of FGF-b expression in lung tissue. (2) FGF-b and C-myc oncogene takes part in reconstruction of pulmonary arterial wall affected by chronic hypoxia.