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[Expression of P21, p53 and proliferating cell nuclear antigen in human bladder cancer]
Objective:
To study the expression of cancer gene product and anti-cancer gene product in the same bladder cancer.
Methods:
Immunohistochemical staining was used to determine the expression of P21, p53 and proliferating cell nuclear antigen (PCNA) in 5 normal bladder tissues and 58 bladder cancers.
Results:
No P21, p53 and PCNA were expressed in the 5 normal bladder tissue samples. The positive incidence of P21, p53 and PCAN expression in the bladder cancers were 62.1%, 55.2% and 58.6% respectively. p53 and PCNA were located in cell nuclei and P21 located on the cell membrane in bladder cancer. The expression of P21, p53 and PCNA correlated to the stage, clinical grade and patient survival rates of this tumor.
Conclusion:
These results suggest that P21, p53 and PCNA immunolabelling may be used to determine the prognosis of bladder cancer patients.