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[Expression of ICAM-1 mRNA in HCC using in situ hybridization technique]
1Gene Therapy Center, Orient Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai.
Objective:
To study the relationship between the intercellular adhesion molecule 1 (ICAM-1) mRNA expression of hepatocellular carcinoma (HCC) and its invasion and metastasis.
Methods:
34 cases of HCC and their pericarcinomatous tissues were studied on cryostat sections by in situ hybridization to investigate ICAM-1 mRNA expression.
Results:
The ICAM-1 mRNA expression was stronger in the carcinomatous tissues of 19/21 invasive cases than that in the pericarcinomatous tissues, while in the 13 non-invasive cases, only 4 exhibited weak ICAM-1 mRNA expression.
Conclusion:
ICAM-1 mRNA expression may correlate with increased risk of invasion and metastasis of HCC.