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[Plasma and skin tissue endothelin in patients with psoriasis vulgaris]
1Department of Dermatology, Second Affiliated Hospital, Hunan Medical University, Changsha.
Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University
|January 1, 1997
Abstract:
The levels of plasma endothelin in 46 patients with psoriasis vulgaris and the levels of endothelin in skin tissue of 25 cases were determined by RIA. The results showed that: (1) The plasma levels of endothelin in patients with psoriasis vulgaris was significantly increased compared with that of the controls (P < 0.01), so was the active stage group compared with the stable stage group (P < 0.01); (2) The level of endothelin in skin lesions of patients was significantly higher than that of the uninvolved skin. These findings suggest that endothelin might play a role in the pathogenesis of psoriasis vulgaris.