Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetics of suicide in depression.

A Roy1, D Nielsen, G Rylander

  • 1Department of Psychiatry at New Jersey VA Healthcare Systems, East Orange Campus, 07018, USA.

The Journal of Clinical Psychiatry
|March 12, 1999
PubMed
Summary

Genetic factors contribute to suicide risk, particularly when combined with stress or psychiatric illness. Family history and specific gene variations, like those affecting serotonin, are implicated in suicidal behavior.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Further evidence for low serum cholesterol and suicidal behaviour.

Journal of affective disorders·2000
Same author

Relation of family history of suicide to suicide attempts in alcoholics.

The American journal of psychiatry·2000
Same author

[Autoimmune hepatitis in children. Initial presentation as fulminant hepatic failure].

Acta gastroenterologica Latinoamericana·2000
Same author

Malnutrition and hypernatraemia in breastfed babies.

Annals of tropical paediatrics·2000
Same author

Somatosensory evoked potentials associated with thermal activation of type II Adelta mechanoheat nociceptive afferents.

The International journal of neuroscience·2000
Same author

Coronary artery bypass grafting without cardiopulmonary bypass in pheochromocytoma.

The Journal of thoracic and cardiovascular surgery·2000

Area of Science:

  • Genetics
  • Psychiatry
  • Neuroscience

Background:

  • Growing evidence suggests genetic factors influence suicide risk.
  • Family history of suicidality is linked to increased risk in psychiatric patients.
  • Twin and adoption studies support a genetic component to suicidal behavior.

Purpose of the Study:

  • To explore the role of genetic factors in the determinants of suicide.
  • To investigate the association between genetic susceptibility, stress, and psychiatric illness in relation to suicide.

Main Methods:

  • Review of clinical studies on psychiatric patients.
  • Analysis of twin and adoption studies.
  • Examination of molecular genetic findings, including gene polymorphisms.

Related Experiment Videos

Main Results:

  • Family history of suicidality is associated with increased risk.
  • Polymorphisms in the tryptophan hydroxylase gene (involved in serotonin synthesis) have been reported.
  • Genetic susceptibility appears to interact with stress or psychiatric illness.

Conclusions:

  • Genetic factors are significant determinants of suicide.
  • Suicidal behavior risk is influenced by a combination of genetic predisposition and environmental/clinical factors.
  • Understanding these genetic links is crucial for suicide prevention strategies.