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Related Experiment Videos

Patch test reactions at D4, D5 and D6.

J Geier1, O Gefeller, K Wiechmann

  • 1Department of Dermatology, University of Göttingen, Germany.

Contact Dermatitis
|March 12, 1999
PubMed
Summary
This summary is machine-generated.

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The best day for a second patch test reading after day 2 is day 3. An additional reading on day 5 maximizes information from patch testing, particularly for slow-reacting allergens.

Area of Science:

  • Dermatology
  • Allergology
  • Contact Dermatitis

Background:

  • Patch testing is crucial for diagnosing allergic contact dermatitis.
  • Optimal timing for patch test readings is essential for accurate diagnosis.
  • Previous studies have varied in recommended reading schedules.

Purpose of the Study:

  • To determine the optimal day for the second patch test reading after day 2.
  • To evaluate the utility of additional patch test readings beyond day 3.
  • To analyze the influence of allergen type and patient characteristics on patch test reactions at later time points (D4-D6).

Main Methods:

  • Retrospective analysis of patch test data from 1990-1995.
  • Three patient groups with readings at D3/D4, D3/D5, and D3/D6.

Related Experiment Videos

  • Comparison of reaction changes (diminishing vs. de novo) between reading days.
  • Subgroup analysis by sex, age, atopy, and specific allergens.

    • Main Results:

    • Significantly more positive patch test reactions diminished than appeared de novo from D3 to later readings.
    • Day 3 is the optimal day for a single second reading after D2, superior to D4.
    • An additional reading on D5 yielded the greatest gain in positive reactions across most patient subgroups and allergens.
    • Slow-reacting allergens (neomycin sulfate, cobalt, p-phenylenediamine) showed increasing reactions from D3 to later readings.

    Conclusions:

    • Day 3 is the recommended day for the second patch test reading.
    • A third reading on day 5 is valuable for maximizing diagnostic yield, especially for specific allergens.
    • Consideration of later readings, including weekends, may be necessary for comprehensive patch testing.