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Updated: Jun 30, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Do enzymes obey the Baldwin rules? A mechanistic imperative in enzymatic cyclization reactions
1Howard Hughes Medical Institute, Departments of Biochemistry, The University of Chicago, 5841 South Maryland Avenue, MC 1028, Chicago, IL 60637, USA. jpicciri@midway uchicago.edu
Abstract:
It is commonly assumed that enzymes have evolved to abide by the same energetic and stereoelectronic principles that govern reactions in solution. The principles formulated for organic ring-closure reactions can be used to develop a hypothesis for analysis of enzyme-catalyzed cyclization reactions.
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