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Acute renal failure from multiple myeloma precipitated by ACE inhibitors
H Rabb1, H Gunasekaran, S Gunasekaran
1Division of Nephrology, Hennepin County Medical Center, Minneapolis, MN 55415, USA. rabbx003@tc.umn.edu
Abstract:
Renal failure in multiple myeloma can be precipitated during hemodynamic perturbances of renal blood flow, as seen secondary to volume depletion, radiocontrast dye, and nonsteroidal anti-inflammatory agents. We report two cases of acute renal failure that developed suddenly after initiation of angiotensin-converting enzyme (ACE) inhibitor, both with biopsy-proven cast nephropathy. ACE inhibitors may contribute to the intratubular light chain cast formation and acute "myeloma kidney" in susceptible patients.
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