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Single-gene influences on brain and behavior.

D Wahlsten1

  • 1Department of Psychology, University of Alberta, Edmonton, Canada. wahlsten@psych.ualberta.ca

Annual Review of Psychology
|March 13, 1999
PubMed
Summary
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Neurobehavioral genetics integrates behavioral and neurogenetics, using gene discovery and knockout models to study brain-behavior links. Research is shifting towards understanding complex gene-environment interactions.

Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Molecular Biology

Background:

  • The emergence of neurobehavioral genetics combines traditional behavioral genetics with neurogenetics.
  • Advances in biotechnology have accelerated gene discovery and the study of gene function in relation to the brain and behavior.
  • Extensive genetic information for various species is now accessible online.

Purpose of the Study:

  • To highlight the development and methodologies within neurobehavioral genetics.
  • To discuss the application of gene knockout models in studying complex phenotypes.
  • To underscore the evolving need for systems-oriented approaches in genetic research.

Main Methods:

  • Gene discovery through new biotechnologies.
  • Creation and utilization of targeted gene knockouts (null mutants).

Related Experiment Videos

  • Analysis of phenotypes such as learning, memory, appetite, obesity, and circadian rhythms.

    • Main Results:

    • Over 7,000 mouse genes and 10,000 human genes have been documented.
    • Gene knockout models are effective tools for studying single-gene effects on various phenotypes.
    • The limitations of a purely reductionistic approach to single-gene effects are becoming apparent.

    Conclusions:

    • Neurobehavioral genetics is a rapidly advancing field driven by technological innovation.
    • The study of gene function in behavior increasingly relies on sophisticated genetic models.
    • A shift towards systems-oriented theories is necessary to understand complex gene-environment interactions.