Biochemistry of vasopressin fragments

Vasopressin (VP) undergoes a step-wise aminopeptidase conversion process in the brain, leading to accumulation of several metabolites. Some of these metabolites, in particular [pGlu4,Cyt6]VP 4-9 and 4-8, show behavioral effects comparable to VP, but are more potent and selective than VP. Most data favor the existence of a separate receptor for the VP metabolites distinct of the classical VP and oxytocin receptors, although its identity has remained obscure thus far. The characterization of this receptor is a major challenge to understand how the brain VP system generates and regulates divers central functions.