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[Listeria monocytogenes--the perfect parasite?].

V B Wyller¹, E A Antal, P Bracht

¹Patologisk-anatomisk avdeling, Ullevål sykehus, Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke

|March 13, 1999

Summary

Listeria monocytogenes bacteria invade host cells, hijack cellular machinery for movement, and spread between cells. This pathogen

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Area of Science:

Molecular biology
Cell biology
Microbiology

Context:

Listeria monocytogenes possesses a unique intracellular life cycle.
The pathogen exploits host cellular mechanisms for invasion and replication.

Purpose:

To review the molecular mechanisms of Listeria monocytogenes infection.
To explore how studying Listeria has advanced understanding of cellular processes.
To propose a mechanism for neuroinvasion.

Summary:

Listeria monocytogenes induces its own phagocytosis and escapes the phagosome.
Intracellular bacteria utilize host actin to form "comet tails" for motility.
Motile bacteria spread to adjacent cells via pseudopodium formation and double-membrane vacuole escape.

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The review proposes actin-dependent axonal transport as the cause of neuroinvasion.

Impact:

Provides insights into the molecular biology of Listeria infection.
Highlights the contribution of Listeria research to understanding fundamental cell biology.
Suggests a novel mechanism for bacterial neuroinvasion via axonal transport.