Pediatric reference ranges for creatine kinase, CKMB, Troponin I, iron, and cortisol

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S J Soldin1, J N Murthy, P K Agarwalla

  • 1Department of Laboratory Medicine, Children's National Medical Center, Washington, DC 20010, USA. ssoldin@cnmc.org

Clinical Biochemistry
|March 13, 1999
PubMed

Insights

This study establishes pediatric reference ranges for iron, cortisol, creatine kinase (CK), CK-myocardial band (CKMB), and troponin I. New data provides vital insights into these biomarkers, particularly for infants.

Area of Science:

  • Biochemistry
  • Pediatric Medicine
  • Clinical Diagnostics

Background:

  • Accurate pediatric reference ranges are crucial for diagnosing various health conditions in children.
  • Existing data for certain biomarkers like CK-myocardial band and troponin I in pediatric populations is limited.
  • Understanding diurnal variations in iron and cortisol levels is important for accurate interpretation.

Purpose of the Study:

  • To establish comprehensive pediatric reference ranges for iron, cortisol, CK, CKMB, and troponin I.
  • To expand the knowledge base on pediatric biomarker reference values.
  • To provide data essential for clinical decision-making in pediatric care.

Main Methods:

  • Utilized the Hoffmann approach to determine pediatric reference ranges on hospitalized patients.
  • Measured iron and CK using the Vitros analyzer.
  • Measured CKMB, troponin I, and cortisol using the Immuno I analyzer.

Main Results:

  • Established pediatric reference ranges for iron (AM/PM) and cortisol (AM/PM).
  • Determined reference ranges for CKMB, troponin I, and total CK.
  • Observed significantly higher 97.5th percentiles for iron in the PM compared to AM.
  • Noted a 10-20% diurnal fluctuation in 97.5th percentiles for cortisol.

Conclusions:

  • This study significantly expands the available pediatric reference range data for key biomarkers.
  • New pediatric reference ranges for CKMB are now available, crucial for early life diagnosis.
  • Novel data on elevated troponin I levels in the first year of life is presented.
Abstract

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