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Chromosomal clues to the development of prostate tumors
A R Brothman1, T M Maxwell, J Cui
1Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132, USA. art.brothman@genetics.utah.edu
Background:
Cytogenetic, molecular cytogenetic, and molecular studies of prostate cancer have revealed an enormous amount of data regarding chromosomal loci that are aberrant in prostate tumors.
Methods:
These data have been compared and condensed in this review to determine which chromosomes and chromosome sites have been most frequently reported.
Results:
Loss of the Y chromosome, gain of 7, 8, and X, and interstitial deletions on 6q, 7q, 8p, 10q, 13q, 16q, 17q, and 18q are the most prevalent.
Conclusions:
A potential model for genetic control of tumor progression is presented, as are data regarding the evaluation of a new series of tumors.