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Updated: Aug 9, 2026

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma
Published on: September 3, 2021
Metastasis of hepatocellular carcinoma to the right colon manifested by gastrointestinal bleeding
C A Cosenza1, L S Sher, B J Poletti
1Comprehensive Liver Disease and Treatment Center and Pathology Department, St. Vincent Medical Center, Los Angeles, California 90057-1974, USA.
Abstract:
An 82-year-old black woman with a history of hepatocellular carcinoma presented with gastrointestinal bleeding. Barium enema and fibrocolonoscopy revealed a 4-cm polypoid mass at the level of the ascending colon with evidence of active bleeding. Biopsies of the lesion proved it to be metastatic hepatocellular carcinoma. Exploratory laparotomy revealed no further dissemination of the tumor, and the patient underwent an ileocolectomy. The serosal side of the colonic lesion was free from tumor, and there was no peritoneal implantation, direct extension, or lymph node involvement. This case represents an extremely rare presentation of metastatic hepatocellular carcinoma.
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