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Genetic conflicts in genomic imprinting.

A Burt1, R Trivers

  • 1Department of Biology, Imperial College, Silwood Park, Ascot, Berkshire, UK. a.burt@ic.ac.uk

Proceedings. Biological Sciences
|March 13, 1999
PubMed
Summary

Genomic imprinting, where gene expression depends on parental origin, involves conflicts between imprinting genes. Relatedness differences drive the evolution of this parent-specific gene regulation.

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Area of Science:

  • Genetics
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Gene expression in mammals and plants can be influenced by parental inheritance.
  • This parent-specific gene expression is known as genomic imprinting.
  • Kinship and relatedness coefficients are crucial factors in the natural selection of imprinted genes.

Purpose of the Study:

  • To explore the role of kinship considerations in the evolution of genomic imprinting.
  • To identify the classes of genes involved in the genomic imprinting mechanism.
  • To analyze the conflicts of interest arising from differing relatedness coefficients among these gene classes.

Main Methods:

  • Theoretical analysis of gene classes involved in genomic imprinting.
  • Examination of parent-specific gene inheritance patterns.
  • Investigation of relatedness coefficients between maternally and paternally derived genes.

Main Results:

  • Three classes of genes are implicated: imprinted genes, parent-acting trans-acting genes, and offspring-acting trans-acting genes.
  • Coefficients of relatedness typically differ among these three gene classes.
  • These differences create conflicts of interest among imprinting-related genes.

Conclusions:

  • Differing relatedness coefficients among imprinting gene classes likely drive the evolution of the imprinting machinery.
  • Genomic imprinting involves complex evolutionary dynamics shaped by kinship.
  • Conflicts between imprinter, imprinted, and imprint-recognition genes have probable evolutionary consequences.

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