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Megathyrin B: a cytotoxic diterpene from Isodon megathyrsus
S X Qiu1, H D Sun, E Lobkovsky
1College of Pharmacy, University of Illinois at Chicago, USA.
Planta Medica
|March 13, 1999
Abstract:
From the leaves of Isodon megathyrsus, a novel ent-kaurene diterpene, megathyrin B, was isolated and its structure determined as 1 alpha,7 beta,11 beta,15 beta-tetrahydroxy-ent-7 alpha,20-epoxy-kaur-16-ene by 1D- and 2D-NMR spectral analysis. Additionally, its stereochemistry was unambiguously assigned by X-ray crystallography. This compound was cytotoxic to the KB and KB-V cell lines.