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Related Experiment Videos

Changes in homocysteine levels during normal pregnancy.

M C Walker1, G N Smith, S L Perkins

  • 1Department of Obstetrics and Gynaecology, University of Ottawa, Canada.

American Journal of Obstetrics and Gynecology
|March 17, 1999
PubMed
Summary

Total plasma homocysteine levels decrease during pregnancy, correlating with lower albumin and increased folic acid intake. These findings are crucial for understanding pregnancy-related metabolic changes.

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Area of Science:

  • Biochemistry
  • Obstetrics
  • Nutritional Science

Background:

  • Elevated homocysteine is a risk factor for adverse pregnancy outcomes.
  • Understanding homocysteine dynamics during pregnancy is essential for maternal and fetal health.

Purpose of the Study:

  • To investigate changes in total plasma homocysteine concentrations throughout normal pregnancy.
  • To correlate homocysteine levels with albumin, vitamin B12, and folate status.

Main Methods:

  • Cross-sectional study of 155 pregnant women across three trimesters and nonpregnant controls.
  • Measurement of plasma homocysteine, albumin, serum B12, serum folate, and red blood cell folate.
  • Statistical analysis to determine correlations and significance.

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Main Results:

  • Homocysteine levels were significantly lower in all trimesters compared to nonpregnant controls (P <.001).
  • Mean homocysteine concentrations varied across trimesters but remained below control levels.
  • Homocysteine showed a direct correlation with albumin levels, which decreased during pregnancy.
  • Folic acid supplementation was associated with decreased homocysteine concentrations.

Conclusions:

  • Pregnancy is associated with a significant decrease in serum homocysteine concentrations.
  • The decline in homocysteine is linked to physiological changes, including reduced albumin levels.
  • Folic acid supplementation plays a role in modulating homocysteine levels during pregnancy.