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Related Experiment Videos

Abnormal response to negative feedback in depression.

P J Shah1, R E O'Carroll, A Rogers

  • 1MRC Brain Metabolism Unit, Royal Edinburgh Hospital.

Psychological Medicine
|March 17, 1999
PubMed
Summary
This summary is machine-generated.

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This study found that depressed patients did not show abnormal responses to negative feedback, contrary to previous suggestions. Healthy controls also did not exhibit a motivational effect from negative feedback.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Previous research suggested depression involves a motivational deficit, with abnormal responses to negative feedback persisting post-recovery.
  • It was hypothesized that negative feedback motivates non-depressed individuals but not those with depression.

Purpose of the Study:

  • To investigate the response to negative feedback in patients with severe depression and schizophrenia.
  • To examine cognitive function and response to perceived failure in depressed patients with diurnal symptom variation.

Main Methods:

  • The simultaneous and delayed match to sample (SDMS) task from the CANTAB neuropsychological test battery was used.
  • Two studies were conducted: one comparing patient groups (depression, acute/chronic schizophrenia) and controls, and another focusing on depressed patients with diurnal variations.

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Main Results:

  • All patient groups demonstrated impairments on the SDMS task compared to controls.
  • Depressed patients did not exhibit an abnormal response to negative feedback, nor did controls show a motivational effect.
  • No variation in response to perceived failure was observed in depressed patients with diurnal variations.

Conclusions:

  • The study did not find evidence supporting an abnormal response to negative feedback in depressed or schizophrenia patient groups.
  • Findings suggest that the hypothesized motivational deficit related to negative feedback may not be a universal characteristic of depression.
  • Further research is recommended to identify potential subgroups of depressed patients who might exhibit abnormal responses to negative feedback.